Protein structural dynamics underlie their evolution and adaptability over the centuries
How does nature utilize the common repertoire of folds in proteins to differentiate their specificity, and ultimately their function? This long-standing and fundamental question was addressed in a study conducted at the Institute of Molecular Biology and Biotechnology of the Foundation for Research & Technology-Hellas (FORTH-IMBB).
IMBB researchers reveal that DNA damage in tissue-infiltrating macrophages triggers an exosome-based metabolic reprogramming leading to chronic inflammation.
Research carried out at the Institute of Molecular Biology and Biotechnology (IMBB) of FORTH, provides evidence that persistent DNA damage triggers an exosome-based, metabolic reprogramming that leads to chronic inflammation and tissue pathology in DNA repair-deficient progeroid syndromes and likely also during aging.
Scientists uncover the role of DNA base excision repair in the pathogenesis of Parkinsonʼs disease
The findings of the study, published today in the premier international scientific journal Cell Reports, reveal a novel molecular mechanism underlying the detrimental effects of BER imbalance in the pathogenesis of Parkinson’s disease.
Cardiotoxicity, as a side effect of breast cancer treatment, at the heart of a new European research project
The new European research project CARDIOCARE, will focus on the management of the elderly multimorbid patients with breast cancer therapy-induced cardiac toxicity.
Discovery of a new Protein, playing a key role in cell function, paves the way for new therapies
Research carried out at the Institute of Molecular Biology and Biotechnology-FORTH and published today in Nature Communications provides evidence that the XAB2 protein functionally links persistent DNA damage with the core spliceosome and the processing of R-loops, highlighting the functional links between genome maintenance and the splicing machinery in development or disease.
A new Research Program at FORTH aims to develop novel therapeutic strategies against Parkinson's disease
Research and Innovation for prevention of cognitive decline: the kick-off meeting of LETHE project
LETHE (λήθη) – A personalized prediction and intervention model for early detection and reduction of risk factors causing dementia, based on AI and distributed Machine Learning
A new international research programme targeting the accurate prognosis and precise treatment of prostate cancer will be coordinated by FORTH
Α big European research project on developing new software tools for the accurate prognosis and precise treatment of prostate cancer, will be coordinated by Prof. Manolis Tsiknakis, Affiliated Professor at the Institute of Computer Science (ICS) of FORTH.
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