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Can_the_three-dimensional_organization_of_the_T_ce
01.01.2023
Can the three-dimensional organization of the T cell genome regulate (auto)immunity?
Biology & Biotechnology, Biosciences, DNA, Health, Nature

The research team's next step, in the field of autoimmunity research, involves the design of highly specific small molecules to be tested for their ability to inhibit inflammation and autoimmunity, initially in a mouse model and later in humans.

Prestigious_ERC_Starting_Grant_awarded_to_FORTH_Re
22.11.2022
Prestigious ERC Starting Grant awarded to FORTH Researcher Dr. Emmanouil Froudarakis
Award, Biology & Biotechnology, Biosciences, ERC

The ERC Starting Grants are awarded to talented early-career scientists, who have already produced excellent work and show potential to be research leaders, to launch their own projects.

Professor_Christos_Louis_honored_for_contributions
01.08.2022
Professor Christos Louis honored for contributions to malaria mosquito biology
Biology & Biotechnology

Professor Christos (Kitsos) Louis, IMBB researcher, was honored for his significant contributions to the understanding of the biology of the malaria mosquito on July 27 at the Mosquito Kolymbari Conference 2022, held at the Orthodox Academy of Crete.

Pathogenic_bacteria_inhibit_host_cell_secretion_to
01.06.2022
Pathogenic bacteria inhibit host cell secretion to manipulate host immunity
Agriculture, Biosciences, Cells, effectors, host susceptibility, Nature, pathogen, Proteins, virulence

In nature, there is a constant evolutionary battle between microbes and their hosts, during which, many bacteria secrete specific proteins into the host’s cells, aiming to alter its physiology, while increasing pestiferous activity.

Clock_gene_mutation_found_to_contribute_to_the_dev
24.03.2022
Clock gene mutation found to contribute to the development of autism
Autism, Biosciences, Health, Neurobiology, Publication

A team of scientists from the University of Minnesota Medical School, University of Texas Health San Antonio, and the Biomedical Research Institute of FORTH, found that the disruption of a circadian clock gene may be involved in the development of autism spectrum disorder.

FORTH_researchers_reveal_how_metabolic_reprogrammi
03.02.2022
FORTH researchers reveal how metabolic reprogramming in mitochondria promotes or undermines survival and longevity
Aging, Biology & Biotechnology, Biosciences, Cells, Collaboration, Disease, Health, Publication

The new findings of the study are published today in the premier international scientific journal Nature Communications.

Protein_structural_dynamics_underlie_their_evoluti
07.12.2021
Protein structural dynamics underlie their evolution and adaptability over the centuries
Biology & Biotechnology, Biosciences, Cells, Proteins, Publication

How does nature utilize the common repertoire of folds in proteins to differentiate their specificity, and ultimately their function? This long-standing and fundamental question was addressed in a study conducted at the Institute of Molecular Biology and Biotechnology of the Foundation for Research & Technology-Hellas (FORTH-IMBB).

IMBB_researchers_reveal_that_DNA_damage_in_tissue-
22.11.2021
IMBB researchers reveal that DNA damage in tissue-infiltrating macrophages triggers an exosome-based metabolic reprogramming leading to chronic inflammation.
Aging, Biology & Biotechnology, Cells, DNA, Health, Publication

Research carried out at the Institute of Molecular Biology and Biotechnology (IMBB) of FORTH, provides evidence that persistent DNA damage triggers an exosome-based, metabolic reprogramming that leads to chronic inflammation and tissue pathology in DNA repair-deficient progeroid syndromes and likely also during aging.

Scientists_uncover_the_role_of_DNA_base_excision_r
07.09.2021
Scientists uncover the role of DNA base excision repair in the pathogenesis of Parkinsonʼs disease
Aging, Biosciences, Cells, Disease, DNA, Health, Neurons, Parkinson's Disease, Publication

The findings of the study, published today in the premier international scientific journal Cell Reports, reveal a novel molecular mechanism underlying the detrimental effects of BER imbalance in the pathogenesis of Parkinson’s disease.

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